The Atholl Palace Hotel
There is a DIRECT train from London Kings Cross at 1200hrs on Fridays, and 0925hrs Monday mornings. The journey takes 6hrs 30mins and is very scenic especially from the Forth Rail Bridge onwards.
The train stops in Pitlochry, a mere 15-minute walk (uphill!) to the hotel - you may wish to book a taxi, costs only a few pounds. Local taxi - 01796 472290 or 01796 473931
The nearest airport is Edinburgh.
From here you could:-
1. Hire a car and drive (1 hour) north
2. Take a train from Edinburgh (you would need to take a bus or taxi to Haymarket Station to connect).
Many people choose to drive. It should take approximately 8 hours from London, 6 hours from Birmingham, or 4.5 hours from Manchester (according to Google).